Alexius

Latinized form of the Greek name Ἀλέξιος (Alexios), a derivative of Ἄλεξις (see Alexis). This was the name of five Byzantine emperors. It was also borne by a 5th-century Syrian saint who is especially venerated in the Eastern Church.
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Alexis

From the Greek name Ἄλεξις (Alexis) meaning “helper” or “defender”, derived from Greek ἀλέξω (alexo) meaning “to defend, to help”. This was the name of a 3rd-century BC Greek comic poet, and also of several saints. It is used somewhat interchangeably with the related name Ἀλέξιος or Alexius, borne by five Byzantine emperors. In the English-speaking world it is more commonly used as a feminine name.
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